15O-water is a very short-lived radioactive version of regular water, in which the oxygen atom has been replaced by oxygen-15, a positron-emitting isotope

IMPORTANT NOTICE: MedTrace’s products are not currently cleared for routine use in any markets, including both the US and Europe. In the US, 15O-water is currently under investigation as an investigational drug in a Phase 3 clinical trial. In Europe, its use is in compliance with approvals granted by national drug authorities, in accordance with the specific legislation of each member state.


15O-water is not metabolized in the body during a PET study.3 15O-water diffuses freely across the cell membrane and is therefore the optimal flow tracer, as its signal is affected only by flow. It has a half-life of 122 seconds, which makes it possible to acquire multiple image scans in rapid sequence.

15O-water has been used as non-invasive gold standard for qualifying a number of methods including myocardial perfusion MR4 and SPECT5, FFR6 and echo7.

The short half-life of 15O-water further means that the patient radioactivity dose is the lowest achievable and down to 0.4 mSv pr. Scan8. The worldwide average natural dose to humans is about 2.4 mSv per year.


This study measures the absolute myocardial blood flow using PET. It also discusses the characteristics of the radioactive tracers, that are available. It is shown that 15O-water is superior to the other tracers.

This comparative study shows that positron emission tomography (PET), using 15O-water as a tracer, exhibits the highest accuracy for diagnosis of myocardial ischemia.

This study examines the cutoff values for absolute MBF and to evaluate the diagnostic accuracy of quantitative 15O-water positron emission tomography (PET). It concludes that the use of 15O-water in PET provides high diagnostic performance for quantitative MBF measurements.

Scientific Applications for 15O-Water





Systems biology