¹⁵O-water enables absolute myocardial blood flow quantification, supporting assessment of coronary artery disease beyond relative perfusion imaging.
Direct Flow Signals
¹⁵O-water is not metabolized during a PET study and diffuses freely across cell membranes, so its PET signal closely reflects blood flow.
Short Half-Life
With a half-life of approximately 122 seconds, ¹⁵O-water supports rapid imaging sequences within a short procedure window.
Reference Method
¹⁵O-water PET has been widely used as a reference method for evaluating other perfusion assessment techniques.
Low Radiation Exposure
The short half-life contributes to low patient radiation exposure, with reported scan doses as low as 0.25 mSv.
Scientific Research Applications for ¹⁵O-Water
Cardiology
Coronary artery disease
Microvascular disease
Heart failure
Neurology
Cerebral ischemia
Neurodegenerative diseases
Oncology
Tumor perfusion
Therapy assessment
Endocrinology
Pancreatic blood flow
Systems biology
Multi-organ blood supply
Ischemic Muscle
Peripheral Artery Disease
